Hybrid isoquinolines from Thalictrum foetidum : a new type of aporphine inhibiting Staphylococcus aureus by combined mechanisms

Hybrid isoquinolines from Thalictrum foetidum : a new type of aporphine inhibiting Staphylococcus aureus by combined mechanisms

Thalfoetines A–D ( 1–4 ), unique hybrid aporphine alkaloids with a C-7 aromatic unit formed by a new C–C bond linking two building blocks, were isolated from Thalictrum foetidum . Their structures were elucidated by extensive spectroscopic and computational analysis. They inhibited bacteria signific...

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Veröffentlicht in:Organic Chemistry Frontiers 2019-10, Vol.6 (19), p.3428-3434
Hauptverfasser: Ding, Cai-Feng, Zhang, Rong-Ping, Yu, Hao-Fei, Yang, Jing, Qin, Xu-Jie, Dai, Zhi, Liu, Ya-Ping, Lu, Qiu-Min, Lai, Ren, Luo, Xiao-Dong
Format: Artikel
Sprache:eng
Schlagworte:
Alkaloids
Computer applications
Cytology
DNA biosynthesis
Organic chemistry
Staphylococcus aureus
Structural damage
Thalictrum
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Zusammenfassung:Thalfoetines A–D ( 1–4 ), unique hybrid aporphine alkaloids with a C-7 aromatic unit formed by a new C–C bond linking two building blocks, were isolated from Thalictrum foetidum . Their structures were elucidated by extensive spectroscopic and computational analysis. They inhibited bacteria significantly, and compound 1 damaged the cell structure of Staphylococcus aureus and inhibited its DNA synthesis.
ISSN:2052-4129
2052-4110
2052-4129
2052-4110
DOI:10.1039/C9QO00737G