Activation of purified cardiac ryanodine receptors by dihydropyridine agonists

Activation of purified cardiac ryanodine receptors by dihydropyridine agonists

Prior observations have raised the possibility that dihydropyridine (DHP) agonists directly affect the sarcoplasmic mreticulum (SR) cardiac Ca2+ release channel [i.e., ryanodine receptor (ryR)]. In single-channel recording of purified canine cardiac RyR, both DHP agonists (-)-BAY K 8644 and (+)-SDZ2...

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Veröffentlicht in:American journal of physiology. Heart and circulatory physiology 2001-03, Vol.49 (3), p.H1201-H1207
Hauptverfasser: SAGAWA, Toshio, NISHIO, Manabu, SAGAWA, Kazuko, KELLY, James E, LOKUTA, Andrew J, TSAI, John, KAN, Edward, WASSERSTROM, J. Andrew
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Sprache:eng
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Biological and medical sciences
Calcium
Dogs
Fundamental and applied biological sciences. Psychology
Heart
Medical research
Vertebrates: cardiovascular system
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container_end_page H1207
container_issue 3
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container_title American journal of physiology. Heart and circulatory physiology
container_volume 49
creator SAGAWA, Toshio
NISHIO, Manabu
SAGAWA, Kazuko
KELLY, James E
LOKUTA, Andrew J
TSAI, John
KAN, Edward
WASSERSTROM, J. Andrew
description Prior observations have raised the possibility that dihydropyridine (DHP) agonists directly affect the sarcoplasmic mreticulum (SR) cardiac Ca2+ release channel [i.e., ryanodine receptor (ryR)]. In single-channel recording of purified canine cardiac RyR, both DHP agonists (-)-BAY K 8644 and (+)-SDZ202-791 incrased the open probability of the RyR when added to the cytoplasmic face of the channel.
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source American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
subjects Biological and medical sciences
Calcium
Dogs
Fundamental and applied biological sciences. Psychology
Heart
Medical research
Vertebrates: cardiovascular system
title Activation of purified cardiac ryanodine receptors by dihydropyridine agonists
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