Activation of purified cardiac ryanodine receptors by dihydropyridine agonists

Prior observations have raised the possibility that dihydropyridine (DHP) agonists directly affect the sarcoplasmic mreticulum (SR) cardiac Ca2+ release channel [i.e., ryanodine receptor (ryR)]. In single-channel recording of purified canine cardiac RyR, both DHP agonists (-)-BAY K 8644 and (+)-SDZ2...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2001-03, Vol.49 (3), p.H1201-H1207
Hauptverfasser:	SAGAWA, Toshio, NISHIO, Manabu, SAGAWA, Kazuko, KELLY, James E, LOKUTA, Andrew J, TSAI, John, KAN, Edward, WASSERSTROM, J. Andrew
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Calcium Dogs Fundamental and applied biological sciences. Psychology Heart Medical research Vertebrates: cardiovascular system
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Zusammenfassung:	Prior observations have raised the possibility that dihydropyridine (DHP) agonists directly affect the sarcoplasmic mreticulum (SR) cardiac Ca2+ release channel [i.e., ryanodine receptor (ryR)]. In single-channel recording of purified canine cardiac RyR, both DHP agonists (-)-BAY K 8644 and (+)-SDZ202-791 incrased the open probability of the RyR when added to the cytoplasmic face of the channel.
ISSN:	0363-6135 1522-1539