Alterations of endothelium-dependent and -independent regulation of coronary blood flow during heart failure

Conflicting data concerning the changes in basal coronary blood flow and nitric oxide (NO)-releasing capacity in chronic heart failure may be due to different phases or duration of heart failure. To investigate endothelium-dependent and -independent regulation of coronary blood flow in different pha...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2002, Vol.51 (1), p.H80-H86
Hauptverfasser:	SAITO, Tomiyoshi, MAEHARA, Kazuhira, TAMAGAWA, Kazuaki, OIKAWA, Yuji, NIITSUMA, Takeo, SAITOH, Shu-Ichi, MARUYAMA, Yukio
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cardiology. Vascular system Circulatory system Coronary vessels Dogs Heart Heart failure Heart failure, cardiogenic pulmonary edema, cardiac enlargement Medical sciences
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Zusammenfassung:	Conflicting data concerning the changes in basal coronary blood flow and nitric oxide (NO)-releasing capacity in chronic heart failure may be due to different phases or duration of heart failure. To investigate endothelium-dependent and -independent regulation of coronary blood flow in different phases of heart failure, coronary pressure-flow relationships during long diastole were obtained before and after rapid pacing of 3 and 5 wk at 240 beats/min in 12 or 6 dogs.
ISSN:	0363-6135 1522-1539