Diabetes and hyperglycemia impair activation of mitochondrial KATP channels

Hyperglycemia is an important predictor of cardiovascular mortality in patients with diabetes. We investigated the hypothesis that diabetes or acute hyperglycemia attenuates the reduction of myocardial infarct size produced by activation of mitochondrial ATP-regulated potassium (KATP) channels.

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Bibliographische Detailangaben
Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2001-04, Vol.49 (4), p.H1744-H1750
Hauptverfasser:	KERSTEN, Judy R, MONTGOMERY, Matthew W, GHASSEMI, Tannaz, GROSS, Eric R, TOLLER, Wolfgang G, PAGEL, Paul S, WARLTIER, David C
Format:	Artikel
Sprache:	eng
Schlagworte:	Associated diseases and complications Biological and medical sciences Coronary vessels Diabetes Diabetes. Impaired glucose tolerance Dogs Endocrine pancreas. Apud cells (diseases) Endocrinopathies Heart attacks Medical sciences Mortality Potassium
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Beschreibung
Zusammenfassung:	Hyperglycemia is an important predictor of cardiovascular mortality in patients with diabetes. We investigated the hypothesis that diabetes or acute hyperglycemia attenuates the reduction of myocardial infarct size produced by activation of mitochondrial ATP-regulated potassium (KATP) channels.
ISSN:	0363-6135 1522-1539