Amlodipine inhibits thapsigargin-sensitive Ca2+ stores in thrombin-stimulated vascular smooth muscle cells

Amlodipine inhibits thapsigargin-sensitive Ca2+ stores in thrombin-stimulated vascular smooth muscle cells

Ca(2+) channel blockers, such as amlodipine, inhibit vascular smooth muscle cell (VSMC) growth through interactions with targets other than L-type Ca(2+) channels. The effects of amlodipine on Ca(2+) movements in thrombin- and thapsigargin-stimulated VSMCs were therefore investigated by determining...

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Veröffentlicht in:American journal of physiology. Heart and circulatory physiology 2000-09, Vol.48 (3), p.H1220-H1227
Hauptverfasser: STEPIEN, Olivier, MARCHE, Pierre
Format: Artikel
Sprache:eng
Schlagworte:
Biochemistry
Biological and medical sciences
Calcium
Cardiovascular system
Cells
Circulatory system
Medical sciences
Pharmacology. Drug treatments
Vascular wall
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Zusammenfassung:Ca(2+) channel blockers, such as amlodipine, inhibit vascular smooth muscle cell (VSMC) growth through interactions with targets other than L-type Ca(2+) channels. The effects of amlodipine on Ca(2+) movements in thrombin- and thapsigargin-stimulated VSMCs were therefore investigated by determining the variations of intracellular free Ca(2+) concentration in fura 2-loaded cultured VSMCs.
ISSN:0363-6135
1522-1539