Nitric oxide reduces energy supply by direct action on the respiratory chain in isolated cardiomyocytes
To investigate the effecto f nitric oxide (NO) on cardiac energy metabolism, isolated cardiomyocytes of Wistar rats were incubated in an Oxystate system oat a constant ambient PO2 (25 mmHg) and oxygen consumption (VO2); free intracellular Ca2+ (fura 2), free cytosolic adenosine [S-adenosylhomocystei...
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| Veröffentlicht in: | American journal of physiology. Heart and circulatory physiology 2001-05, Vol.49 (5), p.H2350-H2356 |
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| container_end_page | H2356 |
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| container_issue | 5 |
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| container_title | American journal of physiology. Heart and circulatory physiology |
| container_volume | 49 |
| creator | STUMPE, Thomas DECKING, Ulrich K. M SCHRADER, Jürgen |
| description | To investigate the effecto f nitric oxide (NO) on cardiac energy metabolism, isolated cardiomyocytes of Wistar rats were incubated in an Oxystate system oat a constant ambient PO2 (25 mmHg) and oxygen consumption (VO2); free intracellular Ca2+ (fura 2), free cytosolic adenosine [S-adenosylhomocysteine (SAH) medthod], and mitochondrila NADH (autofluorescence) were measured after application of the NO donor morpholinosydnonimine (SIN-1). |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0363-6135 |
| ispartof | American journal of physiology. Heart and circulatory physiology, 2001-05, Vol.49 (5), p.H2350-H2356 |
| issn | 0363-6135 1522-1539 |
| language | eng |
| recordid | cdi_proquest_journals_229601621 |
| source | American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Biological and medical sciences Calcium Enzymes Fundamental and applied biological sciences. Psychology Gases Heart Oxygen Respiratory system Vertebrates: cardiovascular system |
| title | Nitric oxide reduces energy supply by direct action on the respiratory chain in isolated cardiomyocytes |
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