Effect of hypercholesterolemia on Ca2+-dependent K+channel-mediated vasodilatation in vivo

Effect of hypercholesterolemia on Ca2+-dependent K+channel-mediated vasodilatation in vivo

Nitric oxide (NO)-mediated and NO-independent mechanisms of endothelium-dependent vasodilatation involve Ca 2+ -dependent K+ (Kca) channels. We examined the role in vivo of K+ channels in NO-independent vasodilatation in hypercholesterolemia. Hindlimb vascular conductance was measured at rest and af...

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Veröffentlicht in:American journal of physiology. Heart and circulatory physiology 2000-10, Vol.48 (4), p.H1600-H1608
Hauptverfasser: JEREMY, Richmond W, MCCARRON, Hugh
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Calcium
Cholesterol
Disorders of blood lipids. Hyperlipoproteinemia
Medical sciences
Metabolic diseases
Rabbits
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Zusammenfassung:Nitric oxide (NO)-mediated and NO-independent mechanisms of endothelium-dependent vasodilatation involve Ca 2+ -dependent K+ (Kca) channels. We examined the role in vivo of K+ channels in NO-independent vasodilatation in hypercholesterolemia. Hindlimb vascular conductance was measured at rest and after aortic injection of ACh, bradykinin (BK), and sodium nitroprusside in anesthetized control and cholesterol-fed rabbits.
ISSN:0363-6135
1522-1539