Bradykinin and des-Arg9-bradykinin metabolic pathways and kinetics of activation of human plasma
In the serum of 116 healthy individuals, exogenous bradykinin (BK) half-life (27 +/- 10 s) was lower than that of des-Arg9-BK (643 +/- 436 s) and was statistically different in men compared with women. The potentiating effect of an angiotensin-converting enzyme (ACE) inhibitor was, however, more ext...
Gespeichert in:
| Veröffentlicht in: | American journal of physiology. Heart and circulatory physiology 2001-07, Vol.50 (1), p.H275-H283 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | H283 |
|---|---|
| container_issue | 1 |
| container_start_page | H275 |
| container_title | American journal of physiology. Heart and circulatory physiology |
| container_volume | 50 |
| creator | CYR, Melanie LEPAGE, Yves BLAIS, Charles JR GERVAIS, Nicole CUGNO, Massimo ROULEAU, Jean-Lucien ADAM, Albert |
| description | In the serum of 116 healthy individuals, exogenous bradykinin (BK) half-life (27 +/- 10 s) was lower than that of des-Arg9-BK (643 +/- 436 s) and was statistically different in men compared with women. The potentiating effect of an angiotensin-converting enzyme (ACE) inhibitor was, however, more extensive for BK (9.0-fold) than for des-Arg9-BK (2.2-fold). |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pasca</sourceid><recordid>TN_cdi_proquest_journals_229600839</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>75432323</sourcerecordid><originalsourceid>FETCH-LOGICAL-p569-1b2e854f6fef80b5f3d4ce76c2cbfb73e06db9d639fd630f4dcc3100f149022a3</originalsourceid><addsrcrecordid>eNpFjUtPwzAQhC0EEqXwHyLE1dLGjp36WCoelSpx6T2sX9QlcYKdgvrvCVCJy4x25tPOGZmVgjFaCq7OyQy45FSWXFySq5z3ACBqyWfk9T6hPb6HGGKB0RbWZbpMb4rq_7xzI-q-DaYYcNx94TH_olPpxmBy0fsCzRg-cQx9_Ll2hw5jMbSYO7wmFx7b7G5OPifbx4ft6pluXp7Wq-WGDkIqWmrmFqLy0ju_AC08t5VxtTTMaK9r7kBarazkyk8CvrLG8BLAl5UCxpDPye3f2yH1HweXx2bfH1KcFhvGlARYcDVBdycIs8HWJ4wm5GZIocN0bEoQvAbJvwEkq16t</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>229600839</pqid></control><display><type>article</type><title>Bradykinin and des-Arg9-bradykinin metabolic pathways and kinetics of activation of human plasma</title><source>American Physiological Society</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>CYR, Melanie ; LEPAGE, Yves ; BLAIS, Charles JR ; GERVAIS, Nicole ; CUGNO, Massimo ; ROULEAU, Jean-Lucien ; ADAM, Albert</creator><creatorcontrib>CYR, Melanie ; LEPAGE, Yves ; BLAIS, Charles JR ; GERVAIS, Nicole ; CUGNO, Massimo ; ROULEAU, Jean-Lucien ; ADAM, Albert</creatorcontrib><description>In the serum of 116 healthy individuals, exogenous bradykinin (BK) half-life (27 +/- 10 s) was lower than that of des-Arg9-BK (643 +/- 436 s) and was statistically different in men compared with women. The potentiating effect of an angiotensin-converting enzyme (ACE) inhibitor was, however, more extensive for BK (9.0-fold) than for des-Arg9-BK (2.2-fold).</description><identifier>ISSN: 0363-6135</identifier><identifier>EISSN: 1522-1539</identifier><identifier>CODEN: AJPPDI</identifier><language>eng</language><publisher>Bethesda, MD: American Physiological Society</publisher><subject>Biochemistry ; Biological and medical sciences ; Enzymes ; Fundamental and applied biological sciences. Psychology ; Kinetics ; Peptides ; Plasma ; Vertebrates: blood, hematopoietic organs, reticuloendothelial system</subject><ispartof>American journal of physiology. Heart and circulatory physiology, 2001-07, Vol.50 (1), p.H275-H283</ispartof><rights>2001 INIST-CNRS</rights><rights>Copyright American Physiological Society Jul 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1053706$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>CYR, Melanie</creatorcontrib><creatorcontrib>LEPAGE, Yves</creatorcontrib><creatorcontrib>BLAIS, Charles JR</creatorcontrib><creatorcontrib>GERVAIS, Nicole</creatorcontrib><creatorcontrib>CUGNO, Massimo</creatorcontrib><creatorcontrib>ROULEAU, Jean-Lucien</creatorcontrib><creatorcontrib>ADAM, Albert</creatorcontrib><title>Bradykinin and des-Arg9-bradykinin metabolic pathways and kinetics of activation of human plasma</title><title>American journal of physiology. Heart and circulatory physiology</title><description>In the serum of 116 healthy individuals, exogenous bradykinin (BK) half-life (27 +/- 10 s) was lower than that of des-Arg9-BK (643 +/- 436 s) and was statistically different in men compared with women. The potentiating effect of an angiotensin-converting enzyme (ACE) inhibitor was, however, more extensive for BK (9.0-fold) than for des-Arg9-BK (2.2-fold).</description><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Enzymes</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Kinetics</subject><subject>Peptides</subject><subject>Plasma</subject><subject>Vertebrates: blood, hematopoietic organs, reticuloendothelial system</subject><issn>0363-6135</issn><issn>1522-1539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNpFjUtPwzAQhC0EEqXwHyLE1dLGjp36WCoelSpx6T2sX9QlcYKdgvrvCVCJy4x25tPOGZmVgjFaCq7OyQy45FSWXFySq5z3ACBqyWfk9T6hPb6HGGKB0RbWZbpMb4rq_7xzI-q-DaYYcNx94TH_olPpxmBy0fsCzRg-cQx9_Ll2hw5jMbSYO7wmFx7b7G5OPifbx4ft6pluXp7Wq-WGDkIqWmrmFqLy0ju_AC08t5VxtTTMaK9r7kBarazkyk8CvrLG8BLAl5UCxpDPye3f2yH1HweXx2bfH1KcFhvGlARYcDVBdycIs8HWJ4wm5GZIocN0bEoQvAbJvwEkq16t</recordid><startdate>20010701</startdate><enddate>20010701</enddate><creator>CYR, Melanie</creator><creator>LEPAGE, Yves</creator><creator>BLAIS, Charles JR</creator><creator>GERVAIS, Nicole</creator><creator>CUGNO, Massimo</creator><creator>ROULEAU, Jean-Lucien</creator><creator>ADAM, Albert</creator><general>American Physiological Society</general><scope>IQODW</scope><scope>7QP</scope><scope>7QR</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20010701</creationdate><title>Bradykinin and des-Arg9-bradykinin metabolic pathways and kinetics of activation of human plasma</title><author>CYR, Melanie ; LEPAGE, Yves ; BLAIS, Charles JR ; GERVAIS, Nicole ; CUGNO, Massimo ; ROULEAU, Jean-Lucien ; ADAM, Albert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p569-1b2e854f6fef80b5f3d4ce76c2cbfb73e06db9d639fd630f4dcc3100f149022a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Enzymes</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Kinetics</topic><topic>Peptides</topic><topic>Plasma</topic><topic>Vertebrates: blood, hematopoietic organs, reticuloendothelial system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CYR, Melanie</creatorcontrib><creatorcontrib>LEPAGE, Yves</creatorcontrib><creatorcontrib>BLAIS, Charles JR</creatorcontrib><creatorcontrib>GERVAIS, Nicole</creatorcontrib><creatorcontrib>CUGNO, Massimo</creatorcontrib><creatorcontrib>ROULEAU, Jean-Lucien</creatorcontrib><creatorcontrib>ADAM, Albert</creatorcontrib><collection>Pascal-Francis</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CYR, Melanie</au><au>LEPAGE, Yves</au><au>BLAIS, Charles JR</au><au>GERVAIS, Nicole</au><au>CUGNO, Massimo</au><au>ROULEAU, Jean-Lucien</au><au>ADAM, Albert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bradykinin and des-Arg9-bradykinin metabolic pathways and kinetics of activation of human plasma</atitle><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle><date>2001-07-01</date><risdate>2001</risdate><volume>50</volume><issue>1</issue><spage>H275</spage><epage>H283</epage><pages>H275-H283</pages><issn>0363-6135</issn><eissn>1522-1539</eissn><coden>AJPPDI</coden><abstract>In the serum of 116 healthy individuals, exogenous bradykinin (BK) half-life (27 +/- 10 s) was lower than that of des-Arg9-BK (643 +/- 436 s) and was statistically different in men compared with women. The potentiating effect of an angiotensin-converting enzyme (ACE) inhibitor was, however, more extensive for BK (9.0-fold) than for des-Arg9-BK (2.2-fold).</abstract><cop>Bethesda, MD</cop><pub>American Physiological Society</pub></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0363-6135 |
| ispartof | American journal of physiology. Heart and circulatory physiology, 2001-07, Vol.50 (1), p.H275-H283 |
| issn | 0363-6135 1522-1539 |
| language | eng |
| recordid | cdi_proquest_journals_229600839 |
| source | American Physiological Society; EZB-FREE-00999 freely available EZB journals |
| subjects | Biochemistry Biological and medical sciences Enzymes Fundamental and applied biological sciences. Psychology Kinetics Peptides Plasma Vertebrates: blood, hematopoietic organs, reticuloendothelial system |
| title | Bradykinin and des-Arg9-bradykinin metabolic pathways and kinetics of activation of human plasma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T10%3A01%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pasca&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Bradykinin%20and%20des-Arg9-bradykinin%20metabolic%20pathways%20and%20kinetics%20of%20activation%20of%20human%20plasma&rft.jtitle=American%20journal%20of%20physiology.%20Heart%20and%20circulatory%20physiology&rft.au=CYR,%20Melanie&rft.date=2001-07-01&rft.volume=50&rft.issue=1&rft.spage=H275&rft.epage=H283&rft.pages=H275-H283&rft.issn=0363-6135&rft.eissn=1522-1539&rft.coden=AJPPDI&rft_id=info:doi/&rft_dat=%3Cproquest_pasca%3E75432323%3C/proquest_pasca%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=229600839&rft_id=info:pmid/&rfr_iscdi=true |