Bradykinin and des-Arg9-bradykinin metabolic pathways and kinetics of activation of human plasma

In the serum of 116 healthy individuals, exogenous bradykinin (BK) half-life (27 +/- 10 s) was lower than that of des-Arg9-BK (643 +/- 436 s) and was statistically different in men compared with women. The potentiating effect of an angiotensin-converting enzyme (ACE) inhibitor was, however, more ext...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2001-07, Vol.50 (1), p.H275-H283
Hauptverfasser:	CYR, Melanie, LEPAGE, Yves, BLAIS, Charles JR, GERVAIS, Nicole, CUGNO, Massimo, ROULEAU, Jean-Lucien, ADAM, Albert
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biological and medical sciences Enzymes Fundamental and applied biological sciences. Psychology Kinetics Peptides Plasma Vertebrates: blood, hematopoietic organs, reticuloendothelial system
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Zusammenfassung:	In the serum of 116 healthy individuals, exogenous bradykinin (BK) half-life (27 +/- 10 s) was lower than that of des-Arg9-BK (643 +/- 436 s) and was statistically different in men compared with women. The potentiating effect of an angiotensin-converting enzyme (ACE) inhibitor was, however, more extensive for BK (9.0-fold) than for des-Arg9-BK (2.2-fold).
ISSN:	0363-6135 1522-1539