Adenosine A2a-receptor activation enhances cardiomyocyte shortening via Ca2+-independent and -dependent mechanisms

Adenosine A2a-receptor activation enhances cardiomyocyte shortening via Ca2+-independent and -dependent mechanisms

Adenosine A2a receptor (A2aR) stimulation enhances the shortening of ventricular myocytes. Whether the A2aR-mediated increase in myocyte contractility is associated with alterations in the amplitude of intracellular Ca2+ transients was investigated in isolated, contracting rat ventricular myocytes u...

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Veröffentlicht in:American journal of physiology. Heart and circulatory physiology 1999-05, Vol.45 (5), p.H1434-H1441
Hauptverfasser: WOODIWISS, A. J, HONEYMAN, T. W, FENTON, R. A, DOBSON, J. G
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Calcium
Cardiology
Cellular biology
Fundamental and applied biological sciences. Psychology
Heart
Rodents
Vertebrates: cardiovascular system
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Zusammenfassung:Adenosine A2a receptor (A2aR) stimulation enhances the shortening of ventricular myocytes. Whether the A2aR-mediated increase in myocyte contractility is associated with alterations in the amplitude of intracellular Ca2+ transients was investigated in isolated, contracting rat ventricular myocytes using the Ca2+-sensitive fluorescent dye fura 2-AM.
ISSN:0363-6135
1522-1539