Changes in ionic currents and beta-adrenergic receptor signaling in hypertrophied myocytes overexpressing Galphaq

Changes in ionic currents and beta-adrenergic receptor signaling in hypertrophied myocytes overexpressing Galphaq

Transgenic overexpression of Galphaq causes cardiac hypertrophy and depressed contractile responses to beta-adrenergic receptor agonists. The electrophysiological basis of the altered myocardial function was examined in left ventricular myocytes isolated from transgenic (Galphaq) mice.

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Bibliographische Detailangaben
Veröffentlicht in:American journal of physiology. Heart and circulatory physiology 2000-07, Vol.48 (1), p.H139
Hauptverfasser: Mitarai, Sayaka, Reed, Thomas D, Yatani, Atsuko
Format: Artikel
Sprache:eng
Schlagworte:
Calcium
Cellular biology
Heart failure
Potassium
Sodium
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Zusammenfassung:Transgenic overexpression of Galphaq causes cardiac hypertrophy and depressed contractile responses to beta-adrenergic receptor agonists. The electrophysiological basis of the altered myocardial function was examined in left ventricular myocytes isolated from transgenic (Galphaq) mice.
ISSN:0363-6135
1522-1539