Aging-associated changes in whole cell K+ and L-type Ca2+ currents in rat ventricular myocytes
The effect of aging on cardiac membrane currents remains unclear. This study examined the inward rectifier K+ current (IK1), the transient outward K+ current (Ito), and the L-type Ca(2+) channel current (ICa,L) in ventricular myocytes isolated from young adult (6 mo) and aged (>27 mo) Fischer 344...
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| Veröffentlicht in: | American journal of physiology. Heart and circulatory physiology 2000-09, Vol.48 (3), p.H889-H900 |
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| container_end_page | H900 |
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| container_issue | 3 |
| container_start_page | H889 |
| container_title | American journal of physiology. Heart and circulatory physiology |
| container_volume | 48 |
| creator | LIU, S. H. I. J WYETH, Richard P MELCHERT, Russell B KENNEDY, Richard H |
| description | The effect of aging on cardiac membrane currents remains unclear. This study examined the inward rectifier K+ current (IK1), the transient outward K+ current (Ito), and the L-type Ca(2+) channel current (ICa,L) in ventricular myocytes isolated from young adult (6 mo) and aged (>27 mo) Fischer 344 rats using whole cell patch-clamp techniques. |
| format | Article |
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H. I. J ; WYETH, Richard P ; MELCHERT, Russell B ; KENNEDY, Richard H</creator><creatorcontrib>LIU, S. H. I. J ; WYETH, Richard P ; MELCHERT, Russell B ; KENNEDY, Richard H</creatorcontrib><description>The effect of aging on cardiac membrane currents remains unclear. This study examined the inward rectifier K+ current (IK1), the transient outward K+ current (Ito), and the L-type Ca(2+) channel current (ICa,L) in ventricular myocytes isolated from young adult (6 mo) and aged (>27 mo) Fischer 344 rats using whole cell patch-clamp techniques.</description><identifier>ISSN: 0363-6135</identifier><identifier>EISSN: 1522-1539</identifier><identifier>CODEN: AJPPDI</identifier><language>eng</language><publisher>Bethesda, MD: American Physiological Society</publisher><subject>Aging ; Biological and medical sciences ; Calcium ; Circulatory system ; Fundamental and applied biological sciences. 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J</creatorcontrib><creatorcontrib>WYETH, Richard P</creatorcontrib><creatorcontrib>MELCHERT, Russell B</creatorcontrib><creatorcontrib>KENNEDY, Richard H</creatorcontrib><title>Aging-associated changes in whole cell K+ and L-type Ca2+ currents in rat ventricular myocytes</title><title>American journal of physiology. Heart and circulatory physiology</title><description>The effect of aging on cardiac membrane currents remains unclear. This study examined the inward rectifier K+ current (IK1), the transient outward K+ current (Ito), and the L-type Ca(2+) channel current (ICa,L) in ventricular myocytes isolated from young adult (6 mo) and aged (>27 mo) Fischer 344 rats using whole cell patch-clamp techniques.</description><subject>Aging</subject><subject>Biological and medical sciences</subject><subject>Calcium</subject><subject>Circulatory system</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heart</subject><subject>Ions</subject><subject>Potassium</subject><subject>Rodents</subject><subject>Vertebrates: cardiovascular system</subject><issn>0363-6135</issn><issn>1522-1539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNotjktLw0AUhQdRsFb_wyDuykDuPDKdZSk-igU3XRtu59GmpJM4kyj59wbt6nDg4zvnisxAcc5ACXNNZoUoBStBqFtyl_OpKAqlSzEjn6tDHQ8Mc25tjb131B4xHnymdaQ_x7bx1Pqmoe8LitHRLevHztM18gW1Q0o-9n9kwp5-TyXVdmgw0fPY2rH3-Z7cBGyyf7jknOxennfrN7b9eN2sV1vWqVIzK7xyZi8NBgjAw3QZ9bK0QXO99zaAE7J0BlHCUkvpNTfBcQcQtBZaFGJOHv-1XWq_Bp_76tQOKU6LFedGGamWeoKeLhBmi01IGG2dqy7VZ0xjBQokGBC_7SlcJg</recordid><startdate>20000901</startdate><enddate>20000901</enddate><creator>LIU, S. H. I. J</creator><creator>WYETH, Richard P</creator><creator>MELCHERT, Russell B</creator><creator>KENNEDY, Richard H</creator><general>American Physiological Society</general><scope>IQODW</scope><scope>7QP</scope><scope>7QR</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20000901</creationdate><title>Aging-associated changes in whole cell K+ and L-type Ca2+ currents in rat ventricular myocytes</title><author>LIU, S. H. I. J ; WYETH, Richard P ; MELCHERT, Russell B ; KENNEDY, Richard H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p567-c3e5d9b49af1f12f539a786cf727becf1d346d9aa418744e729fd2d11f7737303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Aging</topic><topic>Biological and medical sciences</topic><topic>Calcium</topic><topic>Circulatory system</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heart</topic><topic>Ions</topic><topic>Potassium</topic><topic>Rodents</topic><topic>Vertebrates: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LIU, S. H. I. J</creatorcontrib><creatorcontrib>WYETH, Richard P</creatorcontrib><creatorcontrib>MELCHERT, Russell B</creatorcontrib><creatorcontrib>KENNEDY, Richard H</creatorcontrib><collection>Pascal-Francis</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LIU, S. H. I. J</au><au>WYETH, Richard P</au><au>MELCHERT, Russell B</au><au>KENNEDY, Richard H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aging-associated changes in whole cell K+ and L-type Ca2+ currents in rat ventricular myocytes</atitle><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle><date>2000-09-01</date><risdate>2000</risdate><volume>48</volume><issue>3</issue><spage>H889</spage><epage>H900</epage><pages>H889-H900</pages><issn>0363-6135</issn><eissn>1522-1539</eissn><coden>AJPPDI</coden><abstract>The effect of aging on cardiac membrane currents remains unclear. This study examined the inward rectifier K+ current (IK1), the transient outward K+ current (Ito), and the L-type Ca(2+) channel current (ICa,L) in ventricular myocytes isolated from young adult (6 mo) and aged (>27 mo) Fischer 344 rats using whole cell patch-clamp techniques.</abstract><cop>Bethesda, MD</cop><pub>American Physiological Society</pub></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0363-6135 |
| ispartof | American journal of physiology. Heart and circulatory physiology, 2000-09, Vol.48 (3), p.H889-H900 |
| issn | 0363-6135 1522-1539 |
| language | eng |
| recordid | cdi_proquest_journals_229594587 |
| source | American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aging Biological and medical sciences Calcium Circulatory system Fundamental and applied biological sciences. Psychology Heart Ions Potassium Rodents Vertebrates: cardiovascular system |
| title | Aging-associated changes in whole cell K+ and L-type Ca2+ currents in rat ventricular myocytes |
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