Aging-associated changes in whole cell K+ and L-type Ca2+ currents in rat ventricular myocytes

The effect of aging on cardiac membrane currents remains unclear. This study examined the inward rectifier K+ current (IK1), the transient outward K+ current (Ito), and the L-type Ca(2+) channel current (ICa,L) in ventricular myocytes isolated from young adult (6 mo) and aged (>27 mo) Fischer 344...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2000-09, Vol.48 (3), p.H889-H900
Hauptverfasser:	LIU, S. H. I. J, WYETH, Richard P, MELCHERT, Russell B, KENNEDY, Richard H
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Biological and medical sciences Calcium Circulatory system Fundamental and applied biological sciences. Psychology Heart Ions Potassium Rodents Vertebrates: cardiovascular system
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Zusammenfassung:	The effect of aging on cardiac membrane currents remains unclear. This study examined the inward rectifier K+ current (IK1), the transient outward K+ current (Ito), and the L-type Ca(2+) channel current (ICa,L) in ventricular myocytes isolated from young adult (6 mo) and aged (>27 mo) Fischer 344 rats using whole cell patch-clamp techniques.
ISSN:	0363-6135 1522-1539