Chronic regulation of arterial blood pressure by ANP: role of endogenous vasoactive endothelial factors

Atrial natriuretic peptide (ANP) exerts a chronic hypotensive effect due to a decrease in total peripheral resistance (TPR). This study examines if chronic ANP-dependent vasodilation is attributable to differences in the cardiovascular regulatory activity of vascular endothelium (VE), based on evide...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 1998-11, Vol.44 (5), p.H1826-H1833
Hauptverfasser:	MELO, L. G, VERESS, A. T, ACKERMANN, U, SONNENBERG, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blood pressure Cardiology Fundamental and applied biological sciences. Psychology Heart Hemodynamics. Rheology Peptides Vertebrates: cardiovascular system
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Beschreibung
Zusammenfassung:	Atrial natriuretic peptide (ANP) exerts a chronic hypotensive effect due to a decrease in total peripheral resistance (TPR). This study examines if chronic ANP-dependent vasodilation is attributable to differences in the cardiovascular regulatory activity of vascular endothelium (VE), based on evidence that ANP affects synthesis/release and target cardiovascular effects of endothelin-1 (ET-1), C-type natriuretic peptide (CNP), and nitric oxide (NO).
ISSN:	0363-6135 1522-1539