Gene transfer of endothelial nitric oxide synthase (eNOS) in eNOS-deficient mice
Relaxation to acetylcholine (ACh) and calcium ionophore (A-23187) is absent in aortas from endothelial nitric oxide synthase (eNOS)-deficient (eNOS -/-) mice. We hypothesized that gene transfer of eNOS would restore relaxation to ACh and A-23187 in eNOS -/- mice.
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| Veröffentlicht in: | American journal of physiology. Heart and circulatory physiology 1999-08, Vol.46 (2), p.H770-H776 |
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| container_end_page | H776 |
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| container_issue | 2 |
| container_start_page | H770 |
| container_title | American journal of physiology. Heart and circulatory physiology |
| container_volume | 46 |
| creator | LAKE-BRUSE, K. D FARACI, F. M SHESELY, E. G MAEDA, N SIGMUND, C. D HEISTAD, D. D |
| description | Relaxation to acetylcholine (ACh) and calcium ionophore (A-23187) is absent in aortas from endothelial nitric oxide synthase (eNOS)-deficient (eNOS -/-) mice. We hypothesized that gene transfer of eNOS would restore relaxation to ACh and A-23187 in eNOS -/- mice. |
| format | Article |
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D ; FARACI, F. M ; SHESELY, E. G ; MAEDA, N ; SIGMUND, C. D ; HEISTAD, D. D</creator><creatorcontrib>LAKE-BRUSE, K. D ; FARACI, F. M ; SHESELY, E. G ; MAEDA, N ; SIGMUND, C. D ; HEISTAD, D. D</creatorcontrib><description>Relaxation to acetylcholine (ACh) and calcium ionophore (A-23187) is absent in aortas from endothelial nitric oxide synthase (eNOS)-deficient (eNOS -/-) mice. We hypothesized that gene transfer of eNOS would restore relaxation to ACh and A-23187 in eNOS -/- mice.</description><identifier>ISSN: 0363-6135</identifier><identifier>EISSN: 1522-1539</identifier><identifier>CODEN: AJPPDI</identifier><language>eng</language><publisher>Bethesda, MD: American Physiological Society</publisher><subject>Anatomy & physiology ; Animals ; Biological and medical sciences ; Blood vessels ; Classical genetics, quantitative genetics, hybrids ; Fundamental and applied biological sciences. Psychology ; Genes ; Genetics of eukaryotes. 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| fulltext | fulltext |
| identifier | ISSN: 0363-6135 |
| ispartof | American journal of physiology. Heart and circulatory physiology, 1999-08, Vol.46 (2), p.H770-H776 |
| issn | 0363-6135 1522-1539 |
| language | eng |
| recordid | cdi_proquest_journals_229590011 |
| source | American Physiological Society; EZB-FREE-00999 freely available EZB journals |
| subjects | Anatomy & physiology Animals Biological and medical sciences Blood vessels Classical genetics, quantitative genetics, hybrids Fundamental and applied biological sciences. Psychology Genes Genetics of eukaryotes. Biological and molecular evolution Rodents Vertebrata |
| title | Gene transfer of endothelial nitric oxide synthase (eNOS) in eNOS-deficient mice |
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