Gene transfer of endothelial nitric oxide synthase (eNOS) in eNOS-deficient mice

Relaxation to acetylcholine (ACh) and calcium ionophore (A-23187) is absent in aortas from endothelial nitric oxide synthase (eNOS)-deficient (eNOS -/-) mice. We hypothesized that gene transfer of eNOS would restore relaxation to ACh and A-23187 in eNOS -/- mice.

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Bibliographische Detailangaben
Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 1999-08, Vol.46 (2), p.H770-H776
Hauptverfasser:	LAKE-BRUSE, K. D, FARACI, F. M, SHESELY, E. G, MAEDA, N, SIGMUND, C. D, HEISTAD, D. D
Format:	Artikel
Sprache:	eng
Schlagworte:	Anatomy & physiology Animals Biological and medical sciences Blood vessels Classical genetics, quantitative genetics, hybrids Fundamental and applied biological sciences. Psychology Genes Genetics of eukaryotes. Biological and molecular evolution Rodents Vertebrata
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Beschreibung
Zusammenfassung:	Relaxation to acetylcholine (ACh) and calcium ionophore (A-23187) is absent in aortas from endothelial nitric oxide synthase (eNOS)-deficient (eNOS -/-) mice. We hypothesized that gene transfer of eNOS would restore relaxation to ACh and A-23187 in eNOS -/- mice.
ISSN:	0363-6135 1522-1539