Enhanced NO and superoxide generation in dysfunctional hearts from endotoxemic rats

Enhanced NO and superoxide generation in dysfunctional hearts from endotoxemic rats

Free radicals have been implicated in the etiology of cardiac dysfunction during sepsis, but the actual species responsible remains unclear. We studied the alterations in myocardial nitric oxide (NO), superoxide, and peroxynitrite generation along with cardiac mechanical function and efficiency in h...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:American journal of physiology. Heart and circulatory physiology 2002-09, Vol.52 (3), p.H1108-H1115
Hauptverfasser: KHADOUR, Fadi H, PANAS, Donna, FERDINANDY, Péter, SCHULZE, Costas, CSONT, Tamas, LALU, Manoj M, WILDHIRT, Stephen M, SCHULZ, Richard
Format: Artikel
Sprache:eng
Schlagworte:
Bacterial diseases
Biological and medical sciences
Cardiology
Circulatory system
Experimental bacterial diseases and models
Heart
Infectious diseases
Lipids
Medical sciences
Rodents
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Free radicals have been implicated in the etiology of cardiac dysfunction during sepsis, but the actual species responsible remains unclear. We studied the alterations in myocardial nitric oxide (NO), superoxide, and peroxynitrite generation along with cardiac mechanical function and efficiency in hearts from lipopolysaccharide (LPS)-treated rats.
ISSN:0363-6135
1522-1539