Brief murine myocardial I/R induces chemokines in a TNF-(alpha)-independent manner: Role of oxygen radicals

Brief murine myocardial I/R induces chemokines in a TNF-(alpha)-independent manner: Role of oxygen radicals

Early chemokine induction in the area at risk of an ischemic-reperfused (I/R) myocardium is first seen in the venular endothelium. Reperfusion is associated with several induction mechanisms including increased extracellular tumor necrosis factor (TNF)-alpah, reactive oxygen intermediate (ROI) speci...

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Veröffentlicht in:American journal of physiology. Heart and circulatory physiology 2001-12, Vol.50 (6), p.H2549
Hauptverfasser: Nossuli, Tareck O, Frangogiannis, Nikolaos G, Knuefermann, Pascal, Lakshminarayanan, Venkatesh
Format: Artikel
Sprache:eng
Schlagworte:
Cardiology
Cardiovascular disease
Heart
Oxygen
Proteins
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Zusammenfassung:Early chemokine induction in the area at risk of an ischemic-reperfused (I/R) myocardium is first seen in the venular endothelium. Reperfusion is associated with several induction mechanisms including increased extracellular tumor necrosis factor (TNF)-alpah, reactive oxygen intermediate (ROI) species formation, and adhesion of leukocytes to the venular endothelium.
ISSN:0363-6135
1522-1539