Cellular signaling responses mediated by a novel nucleotide receptor in rabbit microvessel endothelium

A study characterizes the agonist profile for three endothelial ATP-linked responses: prostaglandin release, increased intracellular ionized calcium concentration (Ca 2plus i) and inositol phosphate turnover. The study shows that ATP responses in rabbit cardiac muscle microvessel endothelial (RCME)...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 1993-08, Vol.34 (2), p.H675-H680
Hauptverfasser:	MANNIX, R. J, MOATTER, T, KELLEY, K. A, GERRITSEN, M. E
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blood vessels Fundamental and applied biological sciences. Psychology Heart Medical research Rabbits Vertebrates: cardiovascular system
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	A study characterizes the agonist profile for three endothelial ATP-linked responses: prostaglandin release, increased intracellular ionized calcium concentration (Ca 2plus i) and inositol phosphate turnover. The study shows that ATP responses in rabbit cardiac muscle microvessel endothelial (RCME) cells appear to be coupled to a "nucleotide" receptor exhibiting an angonist order of potency similar to that described before in sheep pituitary and human airway epithelial cells.
ISSN:	0363-6135 1522-1539