Adenosine inhibition of neutrophil damage during reperfusion does not involve KATP-channel activation

Adenosine inhibition of neutrophil damage during reperfusion does not involve KATP-channel activation

Zhao et al test the hypothesis that cardioprotection exerted by adenosine A2-receptor activation and neutrophil-related events involves stimulation of ATP-sensitive potassium channels on neutrophils during reperfusion. They conclude that adenosine A2 activation before reperfusion partially reduces i...

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Veröffentlicht in:American journal of physiology. Heart and circulatory physiology 1997-10, Vol.42 (4), p.H1677-H1687
Hauptverfasser: ZHAO, Z.-Q, TODD, J. C, SATO, H, MA, K.-L, VINTEN-JOHANSEN, J
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Cardiology. Vascular system
Coronary heart disease
Heart
Medical sciences
Potassium
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Zusammenfassung:Zhao et al test the hypothesis that cardioprotection exerted by adenosine A2-receptor activation and neutrophil-related events involves stimulation of ATP-sensitive potassium channels on neutrophils during reperfusion. They conclude that adenosine A2 activation before reperfusion partially reduces infarct size by inhibiting neutrophil activity and that this effect does not involve KATP-channel stimulation.
ISSN:0363-6135
1522-1539