Cerebral arteriolar dilations by KATP channel activators need L-lysine or L-arginine

We investigated the effects of various amino acids on responses to ATP-sensitive potassium (KATP) channel openers in anesthetized cats equipped with cranial windows. The application of pinacidil by superfusion caused transient vasodilation, whereas there was sustained vasodilation from the applicati...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 1998-03, Vol.43 (3), p.H974-H981
Hauptverfasser:	KONTOS, H. A, WEI, E. P
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Biological and medical sciences Brain Cats Cellular biology Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Circulatory system Coronary vessels Fundamental and applied biological sciences. Psychology Potassium Vertebrates: nervous system and sense organs
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Zusammenfassung:	We investigated the effects of various amino acids on responses to ATP-sensitive potassium (KATP) channel openers in anesthetized cats equipped with cranial windows. The application of pinacidil by superfusion caused transient vasodilation, whereas there was sustained vasodilation from the application of stationary solution of pinacidil.
ISSN:	0363-6135 1522-1539