Selective upregulation of arterial endothelial nitric oxide synthase in pulmonary hypertension

Resta et al hypothesized that chronic hypoxia selectively upregulates endothelial nitric oxide synthase (eNOS) within the pulmonary arterial vasculature and that monocrotaline-induced pulmonary arterial hypertension selectively enhances pulmonary arterial dilation to endothelium-derived nitric oxide...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 1997-02, Vol.41 (2), p.H806-H813
Hauptverfasser:	RESTA, T. C, GONZALES, R. J, DAIL, W. G, SANDERS, T. C, WALKER, B. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Anatomy & physiology Biological and medical sciences Blood vessels Blood vessels and receptors Enzymes Fundamental and applied biological sciences. Psychology Hypertension Lungs Vertebrates: cardiovascular system
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Beschreibung
Zusammenfassung:	Resta et al hypothesized that chronic hypoxia selectively upregulates endothelial nitric oxide synthase (eNOS) within the pulmonary arterial vasculature and that monocrotaline-induced pulmonary arterial hypertension selectively enhances pulmonary arterial dilation to endothelium-derived nitric oxide-dependent dilators and upregulates arterial eNOS.
ISSN:	0363-6135 1522-1539