Enantiomeric dissection of the effects of the inotropic agent, EMD 53998, in single cardiac myocytes

Enantiomeric dissection of the effects of the inotropic agent, EMD 53998, in single cardiac myocytes

It was ascertained whether the effect of EMD 53998 mediated through PDE III inhibition from that obtained via increased myofilament responsiveness to a calcium ion could be stereo-selectively separated by employing its optical enantiomers, the positive EMD 57033 and the negative EMD 57439. In intact...

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Veröffentlicht in:American journal of physiology. Heart and circulatory physiology 1993-03, Vol.33 (3), p.H728-H738
Hauptverfasser: GAMBASSI, G, CAPOGROSSI, M. C, KLOCKOW, M, LAKATTA, E. G
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Calcium
Cardiotonic agents
Cardiovascular system
Cellular biology
Circulatory system
Medical sciences
Pharmacology. Drug treatments
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Zusammenfassung:It was ascertained whether the effect of EMD 53998 mediated through PDE III inhibition from that obtained via increased myofilament responsiveness to a calcium ion could be stereo-selectively separated by employing its optical enantiomers, the positive EMD 57033 and the negative EMD 57439. In intact cells, the positive inotropic effect of EMD 53998 is due to specific properties of its enantiomers.
ISSN:0363-6135
1522-1539