Compensatory downregulation of myocardial Ca channel in SR from dogs with heart failure

The hypothesis that the ryanodine-binding calcium-release channel activity and density of the sarcoplasmic reticulum (SR) terminal cisterne were decreased in congestive heart failure (CHF) that occurs spontaneously in doberman pinschers or experimentally with rapid ventricular pacing of mongrels was...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 1993-03, Vol.33 (3), p.H926-H937
Hauptverfasser:	CORY, C. R, MCCUTCHEON, L. J, O'GRADY, M, PANG, A. W, GEIGER, J. D, O'BRIEN, P. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Calcium Cardiology. Vascular system Cellular biology Dogs Heart Heart failure, cardiogenic pulmonary edema, cardiac enlargement Medical sciences
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	The hypothesis that the ryanodine-binding calcium-release channel activity and density of the sarcoplasmic reticulum (SR) terminal cisterne were decreased in congestive heart failure (CHF) that occurs spontaneously in doberman pinschers or experimentally with rapid ventricular pacing of mongrels was tested. A microassay demonstrated a 50% decrease in activity of the myocardial SR calcium pump and a 75% reduction in SR calcium-release channel activity in CHF.
ISSN:	0363-6135 1522-1539