Antioxidant treatment for heart failure: friend or foe?

Increasing studies demonstrate a pivotal role for oxidant stress in the pathophysiology of heart failure (HF). Recent meta-analyses also reveal the potential pitfall of a mono-dimensional antioxidant approach. This review article summarizes the main biological pathways involved in oxidant stress and...

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Veröffentlicht in:	QJM : An International Journal of Medicine 2009-05, Vol.102 (5), p.305-310
Hauptverfasser:	Thomson, M. J., Frenneaux, M. P., Kaski, J. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - adverse effects Antioxidants - physiology Biological and medical sciences Cardiology. Vascular system General aspects Heart Heart Failure - drug therapy Heart Failure - etiology Heart failure, cardiogenic pulmonary edema, cardiac enlargement Humans Isoenzymes - physiology Medical sciences Mice Nitric Oxide - physiology Nitric Oxide Synthase - physiology Oxidative Stress - physiology Vitamin E - adverse effects
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Beschreibung
Zusammenfassung:	Increasing studies demonstrate a pivotal role for oxidant stress in the pathophysiology of heart failure (HF). Recent meta-analyses also reveal the potential pitfall of a mono-dimensional antioxidant approach. This review article summarizes the main biological pathways involved in oxidant stress and HF, the possible deleterious nature of certain antioxidant monotherapy and proposes potential antioxidant strategies necessary to challenge specific HF aetiology and progression.
ISSN:	1460-2725 1460-2393
DOI:	10.1093/qjmed/hcn160