Design, Synthesis and Anticancer Activity of 1,2,4-Thiadiazole Derivatives Bearing 1,2,4-Oxadiazole
A series of novel 1,2,4-thiadiazole derivatives bearing 1,2,4-oxadiazole is synthesized. Structures of the synthesized compounds are confirmed by 1 H and 13 C NMR, and mass spectra. All products are evaluated for their anticancer activity towards human cancer cell lines: MCF-7 (breast), A549 (lung),...
Gespeichert in:
| Veröffentlicht in: | Russian journal of general chemistry 2019-08, Vol.89 (8), p.1696-1701 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1701 |
|---|---|
| container_issue | 8 |
| container_start_page | 1696 |
| container_title | Russian journal of general chemistry |
| container_volume | 89 |
| creator | Sudhakar, D. G. S. Rao, A. Srinivasa Reddy, Ch. Venkata Ramana |
| description | A series of novel 1,2,4-thiadiazole derivatives bearing 1,2,4-oxadiazole is synthesized. Structures of the synthesized compounds are confirmed by
1
H and
13
C NMR, and mass spectra. All products are evaluated for their anticancer activity towards human cancer cell lines: MCF-7 (breast), A549 (lung), Colo-205 (colon), and A2780 (ovarian), and demonstrate good to moderate anticancer activity. Four synthesized compounds are characterised by potent activity. |
| doi_str_mv | 10.1134/S1070363219080243 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_journals_2289610938</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A726671432</galeid><sourcerecordid>A726671432</sourcerecordid><originalsourceid>FETCH-LOGICAL-c383t-27cae400e946bacefc81f4c94b9205ad42fc3d127c2303e303d2a32ea36df4bd3</originalsourceid><addsrcrecordid>eNp1kUtPAjEQgDdGExH9Ad428cri9ME-jiv4Skg4gOemdKdQAl1sFyL-ektAjVHTNJ10vm-m6UTRNYEuIYzfjglkwFJGSQE5UM5OohZJIU8Y68FpiEM62efPowvvFwAEIKWtSA3Qm5ntxOOdbeYh9rG0VVzaxihpFbq4VI3ZmmYX1zomHdrhyWRuZGXke73EeIDObGUg0Md3KJ2xsyM1evuELqMzLZcer45nO3p5uJ_0n5Lh6PG5Xw4TxXLWJDRTEjkAFjydSoVa5URzVfBpQaEnK061YhUJGGXAMOyKSkZRsrTSfFqxdnRzqLt29esGfSMW9cbZ0FJQmhcpgSI0-qJmconCWF03TqqV8UqUGU3TjHBGA9X9gwqrwpVRtUVtwv0PgRwE5WrvHWqxdmYl3U4QEPsRiV8jCg49OH69_zh03w_-X_oAxo-PgA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2289610938</pqid></control><display><type>article</type><title>Design, Synthesis and Anticancer Activity of 1,2,4-Thiadiazole Derivatives Bearing 1,2,4-Oxadiazole</title><source>SpringerLink Journals - AutoHoldings</source><creator>Sudhakar, D. G. S. ; Rao, A. Srinivasa ; Reddy, Ch. Venkata Ramana</creator><creatorcontrib>Sudhakar, D. G. S. ; Rao, A. Srinivasa ; Reddy, Ch. Venkata Ramana</creatorcontrib><description>A series of novel 1,2,4-thiadiazole derivatives bearing 1,2,4-oxadiazole is synthesized. Structures of the synthesized compounds are confirmed by
1
H and
13
C NMR, and mass spectra. All products are evaluated for their anticancer activity towards human cancer cell lines: MCF-7 (breast), A549 (lung), Colo-205 (colon), and A2780 (ovarian), and demonstrate good to moderate anticancer activity. Four synthesized compounds are characterised by potent activity.</description><identifier>ISSN: 1070-3632</identifier><identifier>EISSN: 1608-3350</identifier><identifier>DOI: 10.1134/S1070363219080243</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Anticancer properties ; Bearing ; Cancer ; Care and treatment ; Cathepsins ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Colon ; Cystic fibrosis ; Derivatives ; Drug therapy ; Hydrogen bonding ; Mass spectra ; NMR ; Nuclear magnetic resonance ; Oxadiazoles ; Synthesis ; Thiadiazoles</subject><ispartof>Russian journal of general chemistry, 2019-08, Vol.89 (8), p.1696-1701</ispartof><rights>Pleiades Publishing, Ltd. 2019</rights><rights>COPYRIGHT 2019 Springer</rights><rights>Copyright Springer Nature B.V. 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c383t-27cae400e946bacefc81f4c94b9205ad42fc3d127c2303e303d2a32ea36df4bd3</citedby><cites>FETCH-LOGICAL-c383t-27cae400e946bacefc81f4c94b9205ad42fc3d127c2303e303d2a32ea36df4bd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S1070363219080243$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S1070363219080243$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Sudhakar, D. G. S.</creatorcontrib><creatorcontrib>Rao, A. Srinivasa</creatorcontrib><creatorcontrib>Reddy, Ch. Venkata Ramana</creatorcontrib><title>Design, Synthesis and Anticancer Activity of 1,2,4-Thiadiazole Derivatives Bearing 1,2,4-Oxadiazole</title><title>Russian journal of general chemistry</title><addtitle>Russ J Gen Chem</addtitle><description>A series of novel 1,2,4-thiadiazole derivatives bearing 1,2,4-oxadiazole is synthesized. Structures of the synthesized compounds are confirmed by
1
H and
13
C NMR, and mass spectra. All products are evaluated for their anticancer activity towards human cancer cell lines: MCF-7 (breast), A549 (lung), Colo-205 (colon), and A2780 (ovarian), and demonstrate good to moderate anticancer activity. Four synthesized compounds are characterised by potent activity.</description><subject>Anticancer properties</subject><subject>Bearing</subject><subject>Cancer</subject><subject>Care and treatment</subject><subject>Cathepsins</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Colon</subject><subject>Cystic fibrosis</subject><subject>Derivatives</subject><subject>Drug therapy</subject><subject>Hydrogen bonding</subject><subject>Mass spectra</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Oxadiazoles</subject><subject>Synthesis</subject><subject>Thiadiazoles</subject><issn>1070-3632</issn><issn>1608-3350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kUtPAjEQgDdGExH9Ad428cri9ME-jiv4Skg4gOemdKdQAl1sFyL-ektAjVHTNJ10vm-m6UTRNYEuIYzfjglkwFJGSQE5UM5OohZJIU8Y68FpiEM62efPowvvFwAEIKWtSA3Qm5ntxOOdbeYh9rG0VVzaxihpFbq4VI3ZmmYX1zomHdrhyWRuZGXke73EeIDObGUg0Md3KJ2xsyM1evuELqMzLZcer45nO3p5uJ_0n5Lh6PG5Xw4TxXLWJDRTEjkAFjydSoVa5URzVfBpQaEnK061YhUJGGXAMOyKSkZRsrTSfFqxdnRzqLt29esGfSMW9cbZ0FJQmhcpgSI0-qJmconCWF03TqqV8UqUGU3TjHBGA9X9gwqrwpVRtUVtwv0PgRwE5WrvHWqxdmYl3U4QEPsRiV8jCg49OH69_zh03w_-X_oAxo-PgA</recordid><startdate>20190801</startdate><enddate>20190801</enddate><creator>Sudhakar, D. G. S.</creator><creator>Rao, A. Srinivasa</creator><creator>Reddy, Ch. Venkata Ramana</creator><general>Pleiades Publishing</general><general>Springer</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20190801</creationdate><title>Design, Synthesis and Anticancer Activity of 1,2,4-Thiadiazole Derivatives Bearing 1,2,4-Oxadiazole</title><author>Sudhakar, D. G. S. ; Rao, A. Srinivasa ; Reddy, Ch. Venkata Ramana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c383t-27cae400e946bacefc81f4c94b9205ad42fc3d127c2303e303d2a32ea36df4bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Anticancer properties</topic><topic>Bearing</topic><topic>Cancer</topic><topic>Care and treatment</topic><topic>Cathepsins</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Colon</topic><topic>Cystic fibrosis</topic><topic>Derivatives</topic><topic>Drug therapy</topic><topic>Hydrogen bonding</topic><topic>Mass spectra</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Oxadiazoles</topic><topic>Synthesis</topic><topic>Thiadiazoles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sudhakar, D. G. S.</creatorcontrib><creatorcontrib>Rao, A. Srinivasa</creatorcontrib><creatorcontrib>Reddy, Ch. Venkata Ramana</creatorcontrib><collection>CrossRef</collection><jtitle>Russian journal of general chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sudhakar, D. G. S.</au><au>Rao, A. Srinivasa</au><au>Reddy, Ch. Venkata Ramana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Design, Synthesis and Anticancer Activity of 1,2,4-Thiadiazole Derivatives Bearing 1,2,4-Oxadiazole</atitle><jtitle>Russian journal of general chemistry</jtitle><stitle>Russ J Gen Chem</stitle><date>2019-08-01</date><risdate>2019</risdate><volume>89</volume><issue>8</issue><spage>1696</spage><epage>1701</epage><pages>1696-1701</pages><issn>1070-3632</issn><eissn>1608-3350</eissn><abstract>A series of novel 1,2,4-thiadiazole derivatives bearing 1,2,4-oxadiazole is synthesized. Structures of the synthesized compounds are confirmed by
1
H and
13
C NMR, and mass spectra. All products are evaluated for their anticancer activity towards human cancer cell lines: MCF-7 (breast), A549 (lung), Colo-205 (colon), and A2780 (ovarian), and demonstrate good to moderate anticancer activity. Four synthesized compounds are characterised by potent activity.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S1070363219080243</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1070-3632 |
| ispartof | Russian journal of general chemistry, 2019-08, Vol.89 (8), p.1696-1701 |
| issn | 1070-3632 1608-3350 |
| language | eng |
| recordid | cdi_proquest_journals_2289610938 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Anticancer properties Bearing Cancer Care and treatment Cathepsins Chemistry Chemistry and Materials Science Chemistry/Food Science Colon Cystic fibrosis Derivatives Drug therapy Hydrogen bonding Mass spectra NMR Nuclear magnetic resonance Oxadiazoles Synthesis Thiadiazoles |
| title | Design, Synthesis and Anticancer Activity of 1,2,4-Thiadiazole Derivatives Bearing 1,2,4-Oxadiazole |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T01%3A03%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Design,%20Synthesis%20and%20Anticancer%20Activity%20of%201,2,4-Thiadiazole%20Derivatives%20Bearing%201,2,4-Oxadiazole&rft.jtitle=Russian%20journal%20of%20general%20chemistry&rft.au=Sudhakar,%20D.%20G.%20S.&rft.date=2019-08-01&rft.volume=89&rft.issue=8&rft.spage=1696&rft.epage=1701&rft.pages=1696-1701&rft.issn=1070-3632&rft.eissn=1608-3350&rft_id=info:doi/10.1134/S1070363219080243&rft_dat=%3Cgale_proqu%3EA726671432%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2289610938&rft_id=info:pmid/&rft_galeid=A726671432&rfr_iscdi=true |