Design, Synthesis and Anticancer Activity of 1,2,4-Thiadiazole Derivatives Bearing 1,2,4-Oxadiazole

Design, Synthesis and Anticancer Activity of 1,2,4-Thiadiazole Derivatives Bearing 1,2,4-Oxadiazole

A series of novel 1,2,4-thiadiazole derivatives bearing 1,2,4-oxadiazole is synthesized. Structures of the synthesized compounds are confirmed by 1 H and 13 C NMR, and mass spectra. All products are evaluated for their anticancer activity towards human cancer cell lines: MCF-7 (breast), A549 (lung),...

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Veröffentlicht in:Russian journal of general chemistry 2019-08, Vol.89 (8), p.1696-1701
Hauptverfasser: Sudhakar, D. G. S., Rao, A. Srinivasa, Reddy, Ch. Venkata Ramana
Format: Artikel
Sprache:eng
Schlagworte:
Anticancer properties
Bearing
Cancer
Care and treatment
Cathepsins
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Colon
Cystic fibrosis
Derivatives
Drug therapy
Hydrogen bonding
Mass spectra
NMR
Nuclear magnetic resonance
Oxadiazoles
Synthesis
Thiadiazoles
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Beschreibung
Zusammenfassung:A series of novel 1,2,4-thiadiazole derivatives bearing 1,2,4-oxadiazole is synthesized. Structures of the synthesized compounds are confirmed by 1 H and 13 C NMR, and mass spectra. All products are evaluated for their anticancer activity towards human cancer cell lines: MCF-7 (breast), A549 (lung), Colo-205 (colon), and A2780 (ovarian), and demonstrate good to moderate anticancer activity. Four synthesized compounds are characterised by potent activity.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363219080243