A Concise Stereoselective Synthesis of (R)‐2‐Benzylmorpholine and ML398 from (R)‐(−)‐2‐Phenylglycinol

A Concise Stereoselective Synthesis of (R)‐2‐Benzylmorpholine and ML398 from (R)‐(−)‐2‐Phenylglycinol

We describe here an efficient stereoselective method for the preparation of (R)‐2‐benzylmorpholine and ML398. The present method features a high diastereocontrol using an endocyclic oxidation of phenylglycinol‐derived morpholine and a stereoselective alkylation of chiral non‐racemic morpholin‐3‐one...

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Veröffentlicht in:Journal of heterocyclic chemistry 2019-09, Vol.56 (9), p.2677-2682
Hauptverfasser: Torres, Saúl, Velasco, Manuel, Gallegos‐Rojas, José Ángel, Bernès, Sylvain, Orea, María L., Terán, Joel L., Huelgas, Gabriela, Gómez‐Calvario, Víctor, Juárez, Jorge R.
Format: Artikel
Sprache:eng
Schlagworte:
Alkylation
Morpholine
Oxidation
Stereoselectivity
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Zusammenfassung:We describe here an efficient stereoselective method for the preparation of (R)‐2‐benzylmorpholine and ML398. The present method features a high diastereocontrol using an endocyclic oxidation of phenylglycinol‐derived morpholine and a stereoselective alkylation of chiral non‐racemic morpholin‐3‐one as key steps.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.3657