OP66 Effect of pedometer-based walking interventions on long-term health outcomes: prospective 4-year follow-up of 2 randomised controlled trials using routine primary care data

BackgroundData are lacking from physical activity (PA) trials with long-term follow-up of both objectively measured PA levels and robust health outcomes. Two primary care 12-week pedometer-based walking interventions in adults and older adults (PACE-UP and PACE-Lift) found sustained objectively measured PA increases at 3 and 4 years, respectively. Using routine primary care data, we aimed to evaluate intervention effects on long-term health outcomes relevant to walking interventions.MethodsWe downloaded primary care data for trial participants who gave written informed consent, for 4-year periods after their randomisation from the 7 PACE-UP and 3 PACE-Lift English general practices. The following new events were counted masked to intervention status for all participants, including those with pre-existing diseases (apart from diabetes, where existing cases were excluded): non-fatal cardiovascular; total cardiovascular (including fatal); incident diabetes; depression; fractures; and falls. Intervention effects on time to first event post-randomisation were modelled using Cox regression for all outcomes, except for falls, which used Poisson regression to allow for multiple events, adjusting for age, sex, and study. Absolute risk reductions (ARRs) and numbers needed to treat (NNT) were estimated.ResultsData were downloaded for 1297 (98%) of 1321 trial participants. Event rates were low (