Leukocyte Cell‐Derived Chemotaxin‐2: It's Role in Pathophysiology and Future in Clinical Medicine

[...]mice that died at 24 h in the Escherichia coli model had lower levels of circulating LECT2 (15.21 ± 1.03 ng/mL vs. 22.02 ± 1.22 ng/mL; P < 0.001) which may correlate with humans studies that we will discuss below. Unfortunately, β‐catenin is an intracellular protein and is unable to be measured without obtaining a liver biopsy. Because LECT2 is upregulated after Wnt/β‐catenin activation and secreted into the bloodstream, it can be theorized that LECT2 could be used as a reflection of Wnt/β‐catenin activation, liver regeneration, or even as a potential therapeutic target of the Wnt/β‐catenin pathway. [...]after LECT2 administration, these human cell lines were found to have increased lipid accumulation on Oil Red O staining as well. [...]there are preliminary investigations of using LECT2 as a therapeutic target in mice, but human studies, including which drug, dosing, duration of therapy, and specific patient populations, still need to be performed.