Catalyst-free three-component synthesis of 2-amino-4,6-diarylpyridine-3-carbonitriles under solvent-free conditions

Catalyst-free three-component synthesis of 2-amino-4,6-diarylpyridine-3-carbonitriles under solvent-free conditions

A novel efficient one-pot synthesis of 2-amino-4,6-diarylpyridine-3-carbonitriles is described. Method involves heating the mixture of an acetophenone oxime, aldehyde, and malononitrile without any catalyst under solvent-free conditions to give the title compounds in good to high yields.

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Bibliographische Detailangaben
Veröffentlicht in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2019-08, Vol.55 (8), p.725-728
Hauptverfasser: Sayahi, Mohammad Hosein, Saghanezhad, Seyyed Jafar, Mahdavi, Mohammad
Format: Artikel
Sprache:eng
Schlagworte:
Acetophenone
Aldehydes
Catalysis
Catalysts
Chemical synthesis
Chemistry
Chemistry and Materials Science
Malononitrile
Nitriles
Organic Chemistry
Pharmacy
Solvents
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Beschreibung
Zusammenfassung:A novel efficient one-pot synthesis of 2-amino-4,6-diarylpyridine-3-carbonitriles is described. Method involves heating the mixture of an acetophenone oxime, aldehyde, and malononitrile without any catalyst under solvent-free conditions to give the title compounds in good to high yields.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-019-02527-0