Inhaled GM-CSF for Pulmonary Alveolar Proteinosis

In patients with autoimmune pulmonary alveolar proteinosis, the use of inhaled recombinant granulocyte–macrophage colony-stimulating factor resulted in a significantly better alveolar–arterial oxygen gradient at 25 weeks than the use of placebo. The beneficial effect was not observed in smokers.

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Veröffentlicht in:	The New England journal of medicine 2019-09, Vol.381 (10), p.923-932
Hauptverfasser:	Tazawa, Ryushi, Ueda, Takahiro, Abe, Mitsuhiro, Tatsumi, Koichiro, Eda, Ryosuke, Kondoh, Shotaro, Morimoto, Konosuke, Tanaka, Takeshi, Yamaguchi, Etsuro, Takahashi, Ayumu, Oda, Miku, Ishii, Haruyuki, Izumi, Shinyu, Sugiyama, Haruhito, Nakagawa, Atsushi, Tomii, Keisuke, Suzuki, Masaru, Konno, Satoshi, Ohkouchi, Shinya, Tode, Naoki, Handa, Tomohiro, Hirai, Toyohiro, Inoue, Yoshikazu, Arai, Toru, Asakawa, Katsuaki, Sakagami, Takuro, Hashimoto, Atsushi, Tanaka, Takahiro, Takada, Toshinori, Mikami, Ayako, Kitamura, Nobutaka, Nakata, Koh
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Adult Aged Alveoli Autoantibodies Autoantibodies - blood Autoimmune Diseases - diagnostic imaging Autoimmune Diseases - drug therapy Blood pressure Chronic obstructive pulmonary disease Clinical trials Colony-stimulating factor Computed tomography Double-Blind Method Drug Administration Schedule Dyspnea Female Granulocyte-macrophage colony-stimulating factor Granulocyte-Macrophage Colony-Stimulating Factor - administration & dosage Granulocyte-Macrophage Colony-Stimulating Factor - adverse effects Granulocyte-Macrophage Colony-Stimulating Factor - immunology Granulocyte-Macrophage Colony-Stimulating Factor - therapeutic use Humans Immunologic Factors - administration & dosage Immunologic Factors - adverse effects Immunologic Factors - therapeutic use Laboratories Lung - diagnostic imaging Lung - pathology Male Medical research Middle Aged Oxygen - blood Oxygen tension Patients Proteins Pulmonary Alveolar Proteinosis - diagnostic imaging Pulmonary Alveolar Proteinosis - drug therapy Pulmonary Alveolar Proteinosis - immunology Pulmonary Diffusing Capacity R&D Recombinant Proteins - administration & dosage Recombinant Proteins - adverse effects Recombinant Proteins - therapeutic use Research & development Smoking - adverse effects Surfactants Tomography, X-Ray Computed Walk Test
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Beschreibung
Zusammenfassung:	In patients with autoimmune pulmonary alveolar proteinosis, the use of inhaled recombinant granulocyte–macrophage colony-stimulating factor resulted in a significantly better alveolar–arterial oxygen gradient at 25 weeks than the use of placebo. The beneficial effect was not observed in smokers.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa1816216