Four Cases of Severe Hepatotoxicity Associated With Pemoline: Possible Autoimmune Pathogenesis

Rosh et al discuss four cases of marked liver dysfunction in children on pemoline. Two of the cases progressed to fulminant hepatic failure requiring liver transplantation.

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Bibliographische Detailangaben
Veröffentlicht in:	Pediatrics (Evanston) 1998-05, Vol.101 (5), p.921-923
Hauptverfasser:	Rosh, Joel R, Dellert, Susan F, Narkewicz, Michael, Birnbaum, Audrey, Whitington, Gene
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Attention Deficit Disorder with Hyperactivity - drug therapy Attention Deficit Hyperactivity Disorder Autoimmune Diseases - chemically induced Biological and medical sciences Causes of Central Nervous System Stimulants - adverse effects Chemical and Drug Induced Liver Injury - etiology Child Complications and side effects Drug therapy Drug toxicity and drugs side effects treatment Female Hepatic Encephalopathy - chemically induced Humans Jaundice Jaundice - chemically induced Liver Liver failure Male Medical sciences Pediatrics Pemoline Pemoline - adverse effects Pharmaceuticals Pharmacology. Drug treatments Side effects Toxicity: digestive system
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Beschreibung
Zusammenfassung:	Rosh et al discuss four cases of marked liver dysfunction in children on pemoline. Two of the cases progressed to fulminant hepatic failure requiring liver transplantation.
ISSN:	0031-4005 1098-4275
DOI:	10.1542/peds.101.5.921