Triflic anhydride mediated synthesis of 3,4-dihydroquinazolines: a three-component one-pot tandem procedure

A one-pot three-component tandem reaction involving a key PictetSpengler-like annulation step has been developed, providing an efficient method for the synthesis of 3,4-dihydroquinazolines in moderate to good yields from amides, aldehydes, and amines. The multicomponent triflic anhydride mediated reaction tolerates the installation of numerous functional groups, affording extensive diversity about the heterocyclic scaffold. A triflic anhydride mediated one-pot tandem reaction involving a PictetSpengler-like annulation step has been developed for the synthesis of 3,4-dihydroquinazolines.