HPV AND BUSCHKE-LOWENSTEIN DISEASE

Human Papilloma Virus finalize its cycle outside the genital epithelial basement membrane, and the E7 gene of HPV decrease the capacity of the antigen presenting cells in the skin, facilitating the virus to stay hidden for extended periods of time sothe virusavoid the host immune response.In conclusion, E6 and E7 oncogenes damage the host cells to induce telomerase resulting in cellular immortalization of the infected cellsandcause chronic oxidative stress increasing the susceptibility of damaging the DNA and starting the way for carcinogenesis23. Imiquimod, a topically-applied aminoquinoline that is an immune modulator that induces interferon production,was considerdeffective in combination with carbon dioxide laser ablation in unstable patients, who were unable to tolerate surgery, whose tumor was positive for HPV-630. Rev Chim (Bucharest), 2018; 69(8): 2245-50 11 Stanculescu, R; Bratila, E; Bausic, V; Vladescu, T. The triage of low-grade cytological abnormalities by the immunocytological expression of cyclin-dependent kinase inhibitor p16INK4a versus human papillomavirus test: a real possibility to predict cervical intraepithelial neoplasia CIN2 or CIN2+. Stanculescu, R; Bratila, E; Bausic, V; Vladescu, T. The triage of low-grade cytological abnormalities by the immunocytological expression of cyclin-dependent kinase inhibitor p16INK4a versus human papillomavirus test: a real possibility to predict cervical intraepithelial neoplasia CIN2 or CIN2+.