Mn‐Catalyzed Electrochemical Synthesis of Quinazolinones from Primary Alcohols/Benzyl Ethers and o‐Aminobenzamides

An efficient approach for the synthesis of quinazolinones from o‐aminobenzamides and alcohols by the combination of electrochemistry and redox‐metal catalysis has been developed. Taking manganese(II) sulfate as a redox catalyst, this transformation proceeded smoothly under ambient conditions in an undivided cell to afford quinazolinones in moderate to excellent yields with a wide substrate scope. Benzyl ethers were also suitable participants in the cascade cyclization sequence. An efficient electrochemical approach to the synthesis of quinazolinones from o‐aminobenzamides using Mn(II) as a redox‐metal catalyst is presented. Both benzyl alcohols and benzyl ethers are excellent reaction partners in this electrolysis process, producing quinazolinones in satisfying yields with a wide substrate scope under ambient conditions.