Synthesis and Anticancer Activity of Thiophene-2-carboxamide Derivatives and In Silico Docking Studies

Synthesis and Anticancer Activity of Thiophene-2-carboxamide Derivatives and In Silico Docking Studies

A novel series of thiophene-2-carboxamide derivatives are designed and synthesized, and their structures are confirmed by 1 H and 13 C NMR, and mass spectra. The synthesized compounds are evaluated for their in vitro cytotoxic activity by MTT assay. Among the tested compounds, the derivative with 4-...

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Veröffentlicht in:Russian journal of general chemistry 2019-07, Vol.89 (7), p.1502-1512
Hauptverfasser: Gulipalli, K. C., Ravula, P., Bodige, S., Endoori, S., Cherukumalli, P. K. R., Narendra Sharath Chandra, J. N., Seelam, N.
Format: Artikel
Sprache:eng
Schlagworte:
Anticancer properties
Cancer
Chemical synthesis
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Derivatives
Genetic aspects
Mass spectra
Molecular docking
NMR
Nuclear magnetic resonance
Phosphatases
Thiophene
Tyrosine
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Beschreibung
Zusammenfassung:A novel series of thiophene-2-carboxamide derivatives are designed and synthesized, and their structures are confirmed by 1 H and 13 C NMR, and mass spectra. The synthesized compounds are evaluated for their in vitro cytotoxic activity by MTT assay. Among the tested compounds, the derivative with 4-Cl-phenyl ring exhibits potent inhibitory activity against MCF-7, K562, HepG2, and MDA-MB-231. The molecular docking study performed for the synthesized compounds against PTP1B exhibits essential key interactions.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363219070211