Inter-organ proteomic analysis reveals insights into the molecular mechanisms underlying the anti-diabetic effects of cis-9, trans-11 conjugated linoleic acid in ob/ob mice

Unexpectedly, key gluconeogenic enzymes were increased alongside an increased flux through the tricarboxylic acid cycle in their liver, which may indicate a complex coordination between hepatic gluconeogenesis and energy metabolism. [...] multiple positional variants of key regulatory glycogenolytic enzymes were up regulated in their skeletal muscle, with a concurrent decrease in β-oxidation.