High-fat-cholesterol-fed pigs are insulin resistant and have decreased expression of insulin receptor substrate-1 (IRS-1) and PPAR[alpha] in muscle and fat

High-fat-cholesterol-fed pigs are insulin resistant and have decreased expression of insulin receptor substrate-1 (IRS-1) and PPAR[alpha] in muscle and fat

The data suggest that insulin resistance caused by increased lipid intake is associated with decreased adiponectin mRNA expression in adipose tissue despite a compensatory increase in adiponectin receptor 2 expression in muscle and liver.

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Bibliographische Detailangaben
Veröffentlicht in:Proceedings of the Nutrition Society 2008-05, Vol.67 (OCE8)
Hauptverfasser: Lomax, Michael, Karamanlidis, Georgios, Laws, John, Clarke, Lynne
Format: Artikel
Sprache:eng
Schlagworte:
Adipose tissue
Diet
Growth rate
Human subjects
Metabolic syndrome
Metabolism
Tissues
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Zusammenfassung:The data suggest that insulin resistance caused by increased lipid intake is associated with decreased adiponectin mRNA expression in adipose tissue despite a compensatory increase in adiponectin receptor 2 expression in muscle and liver.
ISSN:0029-6651
1475-2719
DOI:10.1017/S0029665108000311