PUFA in the pathogenesis and treatment of patients with multiple sclerosis

Cytokine dysregulation has been found in peripheral blood mononuclear cells (PBMC) during the relapse-remitting phases of MS, i.e. raised TNFα and IL-1β and lack of regulatory transforming growth factor β (TGFβ) production(1), and in an animal model of MS a protective effect of γ-linolenic acid...

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Veröffentlicht in:Proceedings of the Nutrition Society 2008-05, Vol.67 (OCE1), Article E21
Hauptverfasser: Harbige, L. S., Pinto, E., Xiang, M., Leach, M., Sharief, M. K.
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creator Harbige, L. S.
Pinto, E.
Xiang, M.
Leach, M.
Sharief, M. K.
description Cytokine dysregulation has been found in peripheral blood mononuclear cells (PBMC) during the relapse-remitting phases of MS, i.e. raised TNFα and IL-1β and lack of regulatory transforming growth factor β (TGFβ) production(1), and in an animal model of MS a protective effect of γ-linolenic acid (GLA; 18: 3n-6)-rich borage oil associated with raised TGFβ(2).
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subjects Animal models
Fatty acids
Nutrition
Patients
title PUFA in the pathogenesis and treatment of patients with multiple sclerosis
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