Estrogen and progesterone regulate radiation-induced p53 activity in mammary epithelium through TGF-[beta]-dependent pathways

Estrogen and progesterone regulate radiation-induced p53 activity in mammary epithelium through TGF-[beta]-dependent pathways

DNA damage normally induces p53 activity, but responses to ionizing radiation in the mammary epithelium vary among developmental stages. The following studies examined the hormones and growth factors that regulate radiation-responsiveness of p53 in mouse mammary epithelium. Immunoreactive p21/WAF1 a...

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Veröffentlicht in:Oncogene 2005-09, Vol.24 (42), p.6345
Hauptverfasser: Becker, Klaus A, Lu, Shaolei, Dickinson, Ellen S, Dunphy, Karen A, Mathews, Lesley, Sallie Smith Schneider, Jerry, D Joseph
Format: Artikel
Sprache:eng
Schlagworte:
Apoptosis
Cell cycle
Cyclin-dependent kinases
DNA damage
Estrogens
Growth factors
Hormones
Kinases
Radiation
Tumors
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Zusammenfassung:DNA damage normally induces p53 activity, but responses to ionizing radiation in the mammary epithelium vary among developmental stages. The following studies examined the hormones and growth factors that regulate radiation-responsiveness of p53 in mouse mammary epithelium. Immunoreactive p21/WAF1 and TUNEL staining were used as indicators of p53 activity following exposure to ionizing radiation. In ovariectomized mice, radiation-induced accumulation of p21/WAF1 was minimal in the mammary epithelial cells (
ISSN:0950-9232
1476-5594
DOI:10.1038/sj.onc.1208787