Development of Validated Q-absorbance Ratio, Derivative Spectrophotometric and Stability indicating RP-HPLC methods for the simultaneous estimation of Losartan Potassium & Hydrochlorothiazide in Pharmaceutical Dosage Form and comparison of the results by ANOVA

[...]the authors attempted to develop new validated Q- absorbance ratio, Derivative spectrophotometric and Stability indicating RP-HPLC methods for the simultaneous estimation of Losartan Potassium and Hydrochlorothiazide in pharmaceutical dosage form. [...]the authors attempted not only to develop new validated Q- absorbance ratio, Derivative spectroscopic and stability indicating RP-HPLC methods for the simultaneous estimation of Losartan Potassium and Hydrochlorothiazide in pharmaceutical dosage form but also to compare the results obtained using ANOVA. [...]the null hypothesis can be accepted indicating that there was no significant difference among the results obtained from the three proposed methods as shown in Table 11. [...]it can be concluded that any one of the developed methods can be used in the routine analysis of Losartan Potassium and Hydrochlorothiazide in combined tablet dosage forms depending upon the availability of instruments and materials.