Antioxidant, Antidiabetic, and Antihyperlipidemic Activities of Dolichandrone atrovirens in Albino Wistar rats

Results: Dolichandrone atrovirens extract treated animals demonstrated significant increase in body weight, decreased blood glucose levels, glycosylated haemoglobin and changes in other biochemical parameters levels when compared to diabetic control rats. Currently used synthetic antidiabetic agents like sulphonyl ureas, amylin analogs, alpha-glycosidase inhibitors, and biguanides, produce adverse effects, such as lactic acidosis, and in high doses leads to hypoglycaemic coma, diarrhoea and hepato renal disturbances [11,12]. [...]they are not safe to be used during pregnancy [13]. [...]the animal fasted overnight then the blood was collected by cardiac puncture which was used to estimate serum glucose, total cholesterol, triglycerides, glycosylated hemoglobin and serum insulin levels. [...]the present study clearly demonstrates that the Dolichandrone atrovirens leaf and bark extract possess blood glucose lowering potential action in diabetic condition. [...]it has hypolipidemic and antioxidant effects in diabetic animals, therefore it has an ability to prevent the diabetic complications.