Synthesis, Identification, Theoretical Study and effect of Heterocyclic Compounds on the Activity of GOT and GPT Enzymes

The performance of the kidneys is generally tested by observing blood urea nitrogen levels, creatinine clearance and also glomerular filtration rate, the flow rate of purified fluid via the kidney [2]. [...]to urea, creatinine concentrations in body fluids are not influenced by protein consumption, so creatinine levels serve as a more reliable indication of renal function [6]. [...]creatinine quantification is an important research area in science, in particular in the areas of clinical biochemistry, biology and medicine [7,8]. Melting points were measured on Gallen Kamp capillary melting point apparatus and were uncorrected, FT-IR measurements were recorded on Shimadzu model FTIR-8400S. 1HNMR spectra were obtained with Bruker spectrophotometer model ultrashield at 400 MHz in D2O solution with the TMS as internal standard. 2.2.Synthesis of the organic compounds: 2.2.1.Synthesis of compound (1a) [9] Literature procedure was used with modifications. [...]we worked theoretical study For the purpose of comparison with the experimental results, there are good agreement between theoretical and experimental results.