Formulation and Evaluation of Gastroretentive Floating Dosage Forms of Clarithromycin

[...]no adverse effects due to floating devices have been reported to date3. [...]it can be concluded from Fig.1 as the concentration of NaHCo3 increases the floating lag time decreases and floating time increases. [...]the concentration of polymer was increased to 8% for batch FHM2, which showed matrix integrity, but the release of drug was too rapid. [...]HPMC is a suitable polymer for the development of gastric floating drug delivery systems.