Formulation and Evaluation of Fast Dissolving Tablets of Aripiprazole

The dried mass was collected and passed through 60# mesh, then stored in desiccators at room temperature.3-4 Phase Solubility Studies: Solubility measurements were performed according to method reported by Higuchi and Connors. The complexation efficiency (CE), which represents the solubilizing efficiency of the cyclodextrins for the drug, was also calculated from the slope of the phase solubility profile as the ratio of the complex to free cyclodextrin concentration, according to the following equation. 5-6 CE = slope / 1-slope Evaluation of taste masking by E-Tongue Test: All samples were weighed using an analytical balance (±0.5 mg precision) and completely dissolved in appropriate volumes of non de-ionized distilled water at 25°C to obtain the desired concentrations and taste attributes. The reference electrode and the seven-sensor assembly were immersed into each testing beaker for an acquisition time of 120 s. This was followed by sequential immersion into two rinsing beakers containing fresh non de-ionized distilled water for 10 s each to prevent any cross contamination or carry-over residues from previous samples. Wetting Time: Five circular tissue papers of 10 cm diameter are placed in a Petri dish with a 10 cm diameter. 10 ml of water containing Eosin, a water soluble dye is added to Petri dish.