Three modifications in the D and T arms of tRNA influence translation in Escherichia coli and expression of virulene genes in Shigella flexneri

Three modifications in the D and T arms of tRNA influence translation in Escherichia coli and expression of virulene genes in Shigella flexneri

The modified nucleosides 2'-O-methylguanosine, present at position 18, 5-methyluridine, present at position 54, and pseudouridine, present at position 55, are located in the D and T arms of tRNAs and are close in space in the three-dimensional structure of this molecule in the bacterium Escheri...

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Veröffentlicht in:Journal of bacteriology 2002-10, Vol.184 (19), p.5348
Hauptverfasser: Urbonavicius, Jaunius, Durand, Jerome M B, Bjork, Glenn R
Format: Artikel
Sprache:eng
Schlagworte:
Bacteria
Bacteriology
Genes
Mutation
Ribonucleic acid
RNA
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Zusammenfassung:The modified nucleosides 2'-O-methylguanosine, present at position 18, 5-methyluridine, present at position 54, and pseudouridine, present at position 55, are located in the D and T arms of tRNAs and are close in space in the three-dimensional structure of this molecule in the bacterium Escherichia coli. The formation of these modified nucleosides is catalyzed by the product of genes trmH, trmA, and truB.
ISSN:0021-9193
1098-5530