HAR07 encodes chorismate mutase of the methylotrophic yeast Hansenula polymorpha and is derepressed upon methanol utilization

HAR07 encodes chorismate mutase of the methylotrophic yeast Hansenula polymorpha and is derepressed upon methanol utilization

The HAR07 gene of the methylotrophic, thermotolerant yeast Hansenula polymorpha was cloned by functional complementation. HAR07 encodes a monofunctional 280-amino-acid protein with chorismate mutase (EC 5.4.99.5) activity that catalyzes the conversion of chorismate to prephenate, a key step in the b...

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Veröffentlicht in:Journal of bacteriology 2000-08, Vol.182 (15), p.4188
Hauptverfasser: Krappmann, Sven, Pries, Ralph, Gellissen, Gerd, Hiller, Mark, Braus, Gerhard H
Format: Artikel
Sprache:eng
Schlagworte:
Bacteriology
Cloning
Enzymes
Genes
Genetics
Microbiology
Yeast
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Zusammenfassung:The HAR07 gene of the methylotrophic, thermotolerant yeast Hansenula polymorpha was cloned by functional complementation. HAR07 encodes a monofunctional 280-amino-acid protein with chorismate mutase (EC 5.4.99.5) activity that catalyzes the conversion of chorismate to prephenate, a key step in the biosynthesis of aromatic amino acids.
ISSN:0021-9193
1098-5530
DOI:10.1128/JB.182.15.4188-4197.2000