Utilization of orotate as a pyrimidine source by Salmonella typhimurium and Escherichoia coli requires the dicarboxylate transport protein encoded by dctA

Baker et al investigated the biochemical and genetic characterization of orotate utilization in Salmonella typhimurium with some related studies on Escherichia coli. They ultimately established the involvement of the dicarboxylate transport system in orotate utilization and identified the product of the dctA gene in mediating the entry of orotate into the cell.